Wwtr1^tm1Benj
Targeted Allele Detail

Summary

• Symbol: Wwtr1^tm1Benj
• Name: WW domain containing transcription regulator 1; targeted mutation 1, Thomas Benjamin
• MGI ID: MGI:3759999
• Synonyms: TAZ^-
• Gene: Wwtr1 Location: Chr3:57363070-57483331 bp, - strand Genetic Position: Chr3, 27.74 cM
• Alliance: Wwtr1^tm1Benj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125326
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a SA-Betagal PGK-neo cassette such that the remaining open reading frame would be out of frame. Exon 2 encodes a 144 amino acid stretch containing the 14-3-3 binding domain and the WW domain. A western blot of protein extracts from mouse embryonic fibroblasts with a C-terminal antibody confirmed the absence of protein expression. (J:125326)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wwtr1 Mutation: 26 strains or lines available

References

• Original: J:125326 Tian Y, et al., TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol. 2007 Sep;27(18):6383-95
• All: 10 reference(s)