Chn1^mfy
Spontaneous Allele Detail

Summary

• Symbol: Chn1^mfy
• Name: chimerin 1; miffy
• MGI ID: MGI:3760001
• Synonyms: alpha-Chn^mfy, mfy
• Gene: Chn1 Location: Chr2:73441004-73605690 bp, - strand Genetic Position: Chr2, 43.78 cM
• Alliance: Chn1^mfy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: A retroposon insertion into exon 9 resulted in deletion of exon 9 (174 bp) in the alpha1 and alpha2 transcripts, and deletion of four nucleotides (including the putative initiation codon) and failure of intron 9 splicing in the alpha3 transcript. Partial rescue of the locomotor phenotype with an alpha-chimerin Tg was used as evidenct that Chn was the causal gene of the mutation. (J:125703)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Chn1 Mutation: 44 strains or lines available

Notes

Genbank sequences for this mutation: AB264771, AB264772, and AB264773

References

• Original: J:125703 Iwasato T, et al., Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell. 2007 Aug 24;130(4):742-53
• All: 3 reference(s)