Chn1^tm1.1Ito
Targeted Allele Detail

Summary

• Symbol: Chn1^tm1.1Ito
• Name: chimerin 1; targeted mutation 1.1 Shigeyoshi Itohara
• MGI ID: MGI:3760002
• Synonyms: alpha-Chn KO
• Gene: Chn1 Location: Chr2:73441004-73605690 bp, - strand Genetic Position: Chr2, 43.78 cM
• Alliance: Chn1^tm1.1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125703
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP-flanked genomic sequences containing exons 9 and 10 were deleted by cre-mediated recombination. A single loxP site remains in place of a KpnI-HindIII fragment of this gene. Western blot analyses using an alpha2-chimerin-specific antibody confirmed no expression of the encoded protein in homozygous mice. (J:125703)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chn1 Mutation: 44 strains or lines available

References

• Original: J:125703 Iwasato T, et al., Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell. 2007 Aug 24;130(4):742-53
• All: 5 reference(s)