Hspb1^tm1Msk
Targeted Allele Detail

Summary

• Symbol: Hspb1^tm1Msk
• Name: heat shock protein 1; targeted mutation 1, Demetrius Moskophidis
• MGI ID: MGI:3760083
• Synonyms: hspb1^-
• Gene: Hspb1 Location: Chr5:135916773-135918417 bp, + strand Genetic Position: Chr5, 75.51 cM
• Alliance: Hspb1^tm1Msk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125325
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 60% of the coding region from the ATG start codon to exon 2 was replaced with a lacZ and floxed neo cassette. Mice were bred to B6-Cre mice to remove the neo cassette. The absence of protein product was confirmed by western blot analysis of protein extracted from tongue homogenates. (J:125325)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspb1 Mutation: 18 strains or lines available

References

• Original: J:125325 Huang L, et al., Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007 Aug;45(8):487-501
• All: 1 reference(s)