Krt19^tm1Alki
Targeted Allele Detail

Summary

• Symbol: Krt19^tm1Alki
• Name: keratin 19; targeted mutation 1, Abraham L Kierszenbaum
• MGI ID: MGI:3760085
• Synonyms: K9^neo
• Gene: Krt19 Location: Chr11:100031636-100036752 bp, - strand Genetic Position: Chr11, 63.42 cM
• Alliance: Krt19^tm1Alki page

Krt19^tm1Alki/Krt19^tm1Alki spermatids exhibit ectopic manchettes

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125621
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Dominant negative, Hypomorph)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into intron 6. In the wild-type allele this intron is always spliced out but in the mutated allele in some transcripts only part of intron 6 (between neo and exon 7) is spliced out, resulting in the expression of both wild-type and truncated protein product. Expression of the truncated and full length protein products was confirmed by western blot analysis on protein extracted from the epidermis. (J:125621)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt19 Mutation: 21 strains or lines available

References

• Original: J:125621 Rivkin E, et al., Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene. Mol Reprod Dev. 2005 Oct;72(2):259-71
• All: 1 reference(s)