Magel2^tm1Stw
Targeted Allele Detail

Summary

• Symbol: Magel2^tm1Stw
• Name: MAGE family member L2; targeted mutation 1, Colin L Stewart
• MGI ID: MGI:3760092
• Synonyms: Magel2^-
• Gene: Magel2 Location: Chr7:62026758-62031388 bp, + strand Genetic Position: Chr7, 34.37 cM
• Alliance: Magel2^tm1Stw page

Older Magel2^tm1Stw/Magel2⁺ females that inherit the mutant allele paternally lack corpora lutea in the ovaries

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125637
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire open reading frame was replaced with a lacZ-neo cassette. The endogenous promoter drives the expression of lacZ as confirmed by a beta-galactosidase assay. The absence of the paternal transcript was confirmed by RT-PCR. (J:125637)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Magel2 Mutation: 60 strains or lines available

References

• Original: J:125637 Kozlov SV, et al., The imprinted gene Magel2 regulates normal circadian output. Nat Genet. 2007 Oct;39(10):1266-72
• All: 17 reference(s)