Rr250409^tm1Lky
Targeted Allele Detail

Summary

• Symbol: Rr250409^tm1Lky
• Name: regulatory region 250409; targeted mutation 1, Richard M Locksley
• MGI ID: MGI:3760155
• Synonyms: Cigs1^tm1Lky, CNS-1^-, CNS-I^-
• Gene: Rr250409 Location: Chr11:53517402-53519171 bp, . strand Genetic Position: Chr11, Syntenic
• Alliance: Rr250409^tm1Lky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125684
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: The 489 bp conserved enhancer between Il13 and Il4 was replaced with a loxP site flanked neomycin resistance gene cassette that was subsequently removed following a cross with Tg(MMTV-cre)1Mam mice. The absence of the enhancer was confirmed by Southern blot analysis. (J:125684)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr250409 Mutation: 0 strains or lines available

References

• Original: J:125684 Mohrs M, et al., Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immunol. 2001 Sep;2(9):842-7
• All: 3 reference(s)