Wasl^tm2Sbs
Targeted Allele Detail

Summary

• Symbol: Wasl^tm2Sbs
• Name: WASP like actin nucleation promoting factor; targeted mutation 2, Scott B Snapper
• MGI ID: MGI:3760279
• Synonyms: N-WASp^fl, N-WASP L2L
• Gene: Wasl Location: Chr6:24613804-24665008 bp, - strand Genetic Position: Chr6, 11.28 cM, cytoband A3
• Alliance: Wasl^tm2Sbs page

Hypoplasia and loss of glomeruli and proximal tubules in Wasl^tm2Sbs/Wasl^tm2Sbs Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ kidneys

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125309
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstrem of exon 2 and an additional loxP site upstream of exon 2. The neo cassette was deleted by transient Cre recombinase expression. Insertion was confirmed by Southern blot analysis. (J:125309)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wasl Mutation: 39 strains or lines available

References

• Original: J:125309 Cotta-de-Almeida V, et al., Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15424-9
• All: 17 reference(s)