Tg(CD74)AR194Ayr
Transgene Detail

Summary

• Symbol: Tg(CD74)AR194Ayr
• Name: transgene insertion AR194, Alexander Y Rudensky
• MGI ID: MGI:3760406
• Synonyms: hIi, hIi^WT
• Transgene: Tg(CD74)AR194Ayr Location: unknown
• Alliance: Tg(CD74)AR194Ayr page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1 x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD74)AR194Ayr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD74 (972)

  Cd74	(MGI:96534)

• Mutation details: A vector containing the human class II-associated invariant chain gene (hIi, CD74) and promoter was injected into (C57BL/6J x DBA/2J)F1 x C57BL/6J embryos. This line (AR194) was initially backcrossed to C57BL/6-congenic invariant chain targeted mutant mice and later crossed with inbred C57BL/6 animals for a total of more than 12 generations by the donating investigator. This line no longer carries the invariant chain targeted mutation. (J:88717)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:88717 Honey K, et al., Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M. J Immunol. 2004 Apr 1;172(7):4142-50
• All: 1 reference(s)