Tg(SFTPC-CCNE1*T62A*T380A)3Edm
Transgene Detail

Summary

• Symbol: Tg(SFTPC-CCNE1*T62A*T380A)3Edm
• Name: transgene insertion 3, Ethan Dmitrovsky
• MGI ID: MGI:3760419
• Transgene: Tg(SFTPC-CCNE1*T62A*T380A)3Edm Location: unknown
• Alliance: Tg(SFTPC-CCNE1*T62A*T380A)3Edm page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-CCNE1*T62A*T380A)3Edm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CCNE1 (898)

  Ccne1

  (MGI:88316)

• Mutation details: A "degradation resistant" human cyclin E cDNA was placed under the control of the human surfactant protein C promoter which causes expression in alveolar type II and bronchioalveolar cells. The protein expressed by this transgenes has a threonine for alanine substitution at amino acid residues 62 and 380. Transgenic protein was detected immunologically. Expression of this transgenic line occurs at a low level. (J:122698)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(SFTPC-CCNE1*T62A*T380A)3Edm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122698 Ma Y, et al., Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4089-94
• All: 1 reference(s)