Pstpip2^Lupo
Chemically induced Allele Detail

Summary

• Symbol: Pstpip2^Lupo
• Name: proline-serine-threonine phosphatase-interacting protein 2; Lupo
• MGI ID: MGI:3760548
• Synonyms: Mayp^Lp
• Gene: Pstpip2 Location: Chr18:77882250-77971462 bp, + strand Genetic Position: Chr18, 52.38 cM, cytoband E3
• Alliance: Pstpip2^Lupo page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU-induced mutagenesis was used to generate an allele with a T to A transition that results in an amino acid substitution of isoleucine to asparganine at position 282 (I282N). (J:125785)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pstpip2 Mutation: 25 strains or lines available

References

• Original: J:125785 Grosse J, et al., Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. Blood. 2006 Apr 15;107(8):3350-8
• All: 2 reference(s)