Map3k12^{Gt(RRN366)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Map3k12^{Gt(RRN366)Byg}
• Name: mitogen-activated protein kinase kinase kinase 12; gene trap RRN366, BayGenomics
• MGI ID: MGI:3760641
• Synonyms: DLK, zpk^tp
• Gene: Map3k12 Location: Chr15:102406079-102425311 bp, - strand Genetic Position: Chr15, 57.63 cM, cytoband F3
• Alliance: Map3k12^{Gt(RRN366)Byg} page

Mutation origin

• Mutant Cell Line: RRN366
• Germline Transmission: Earliest citation of germline transmission: J:125702
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The gene trap vector pGT0Lxf was inserted into an intron in the 5' untranslated region. This allele is strongly hypomorphic. (J:125702)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRN366	CG671895 ; (MGI Seq Detail)	5' RACE	Chr15:102417725-102425270 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  16 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map3k12 Mutation: 39 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:125702 Bloom AJ, et al., The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons. Genes Dev. 2007 Oct 15;21(20):2593-606
• All: 7 reference(s)