Ankrd1^tm1Krc
Targeted Allele Detail

Summary

• Symbol: Ankrd1^tm1Krc
• Name: ankyrin repeat domain 1; targeted mutation 1, Kenneth R Chien
• MGI ID: MGI:3760783
• Gene: Ankrd1 Location: Chr19:36089365-36097244 bp, - strand Genetic Position: Chr19, 30.52 cM, cytoband C3
• Alliance: Ankrd1^tm1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125819
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 2 exons were replaced by cDNA encoding lacZ and a pGK neo cassette, bringing the beta-galactosidase cDNA under the control of the endogenous promoter while ablating the endogenous gene. Northern and Western blot analysis on heart confirmed absence of Ankrd2 RNA and protein, respectively. (J:125819, J:215212)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ankrd1 Mutation: 21 strains or lines available

References

• Original: J:125819 Barash IA, et al., Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Am J Physiol Cell Physiol. 2007 Jul;293(1):C218-27
• All: 3 reference(s)