Ankrd23^tm1Krc
Targeted Allele Detail

Summary

• Symbol: Ankrd23^tm1Krc
• Name: ankyrin repeat domain 23; targeted mutation 1, Kenneth R Chien
• MGI ID: MGI:3760785
• Gene: Ankrd23 Location: Chr1:36569269-36575964 bp, - strand Genetic Position: Chr1, 15.31 cM
• Alliance: Ankrd23^tm1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125819
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 3 exons were replaced by cDNA encoding lacZ and a pGK neo cassette, bringing the beta-galactosidase cDNA under the control of the endogenous promoter while ablating the endogenous gene. Northern and Western blot analysis on skeletal muscle and heart confirmed absence of Ankrd2 RNA and protein, respectively. (J:125819, J:215212)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ankrd23 Mutation: 6 strains or lines available

References

• Original: J:125819 Barash IA, et al., Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Am J Physiol Cell Physiol. 2007 Jul;293(1):C218-27
• All: 4 reference(s)