Rr97tm3Welm
Targeted Allele Detail
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| Symbol: |
Rr97tm3Welm |
| Name: |
regulatory region 97; targeted mutation 3, Wilfried Ellmeier |
| MGI ID: |
MGI:3761127 |
| Synonyms: |
Cd8a/Cd8b1tm3Welm, delta2delta3 |
| Gene: |
Rr97 Location: unknown Genetic Position: Chr6, Syntenic
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| Alliance: |
Rr97tm3Welm page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:126027
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Modified regulatory region, Null/knockout) |
| Mutation: |
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Intergenic deletion
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Mutation details: A 804 bp genomic fragment immediately downstream of the Cd8b1 untranslated region that contains the "core" of the E8iii enhancer and an adjacent 4.4kb genomic fragment that contains the entire E8ii enhancer was replaced by a floxed neomycin resistance cassette. Heterozygous mice were bred with cre-transgenic mice to remove the neomycin cassette, leaving a single loxP site. Southern blotting confirmed deletion of the enhancer elements.
(J:126027)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Rr97 Mutation: |
0 strains or lines available
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| Original: |
J:126027 Feik N, et al., Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development. J Immunol. 2005 Feb 1;174(3):1513-24 |
| All: |
2 reference(s) |
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Analysis Tools
