Tg(MMTV-neu/OT-I/OT-II)CBnel
Transgene Detail

Summary

• Symbol: Tg(MMTV-neu/OT-I/OT-II)CBnel
• Name: transgene insertion C, Brad Nelson
• MGI ID: MGI:3761163
• Synonyms: MMTV-HER2/Neu-Ovalbumin, neu^OT-I/OT-II
• Transgene: Tg(MMTV-neu/OT-I/OT-II)CBnel Location: unknown
• Alliance: Tg(MMTV-neu/OT-I/OT-II)CBnel page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-neu/OT-I/OT-II)CBnel expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

• Mutation details: The transgene construct was designed to tag T cell receptor-recognized ovalbumin epitopes SIIFEKL (CD8⁺, OT-1) and ISQAVHAAHAEINEAGR (CD4⁺, OT-II)with the rat Erbb2/HER-2/neu oncogene under the control of an MMTV promoter creating a fusion protein (termed neu^OT-I/OT-II). The vector was injected into C57BL/6 oocytes. Line C was selected for further studies based on mammary-specific expression and favorable tumor latency and frequency. (J:122846)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:122846 Wall EM, et al., Spontaneous mammary tumors differ widely in their inherent sensitivity to adoptively transferred T cells. Cancer Res. 2007 Jul 1;67(13):6442-50
• All: 4 reference(s)