Tg(Tcra5CC7,Tcrb5CC7)IWep
Transgene Detail

Summary

• Symbol: Tg(Tcra5CC7,Tcrb5CC7)IWep
• Name: transgene insertion I, William E Paul
• MGI ID: MGI:3761187
• Synonyms: 5C.C7, 5CC7 TCR, 5cc7 TCR-Tg, Cyt5CC7, TCR-Cyt-5CC7-I, [Tg]TCRCyt5CC7-I
• Transgene: Tg(Tcra5CC7,Tcrb5CC7)IWep Location: unknown
• Alliance: Tg(Tcra5CC7,Tcrb5CC7)IWep page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra5CC7,Tcrb5CC7)IWep expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Rearranged mouse alpha and beta TCR were derived from DNA of the 5C.C7 T cell clone which originated from mice immunized with pigeon cytochrome c. The Tcr Valpha11.1 JalphaC7 construct lacks the 3' alpha enhancer and the Tcr Vbeta3 Dbeta1.1 Jbeta1.2 construct includes the endogenous 3' beta-chain enhancer. The transgene is expressed in more than 95% of all CD4+ cells on the original B10.BR background. (J:111186)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available

References

• Original: J:124386 Seder RA, et al., The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med. 1992 Oct 1;176(4):1091-8
• All: 73 reference(s)