Tg(Tcra5CC7,Tcrb5CC7)IWep
Transgene Detail

Summary

• Symbol: Tg(Tcra5CC7,Tcrb5CC7)IWep
• Name: transgene insertion I, William E Paul
• MGI ID: MGI:3761187
• Synonyms: 5C.C7, 5CC7 TCR, 5cc7 TCR-Tg, Cyt5CC7, TCR-Cyt-5CC7-I, [Tg]TCRCyt5CC7-I
• Transgene: Tg(Tcra5CC7,Tcrb5CC7)IWep Location: unknown
• Alliance: Tg(Tcra5CC7,Tcrb5CC7)IWep page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra5CC7,Tcrb5CC7)IWep expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Rearranged mouse alpha and beta TCR were derived from DNA of the 5C.C7 T cell clone which originated from mice immunized with pigeon cytochrome c. The Tcr Valpha11.1 JalphaC7 construct lacks the 3' alpha enhancer and the Tcr Vbeta3 Dbeta1.1 Jbeta1.2 construct includes the endogenous 3' beta-chain enhancer. The transgene is expressed in more than 95% of all CD4+ cells on the original B10.BR background. (J:111186)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Gata3^tm1Jfz/Gata3^tm1Jfz Rag2^tm1Fwa/Rag2^tm1Fwa Tg(Cd4-cre)1Cwi/0 Tg(Tcra5CC7,Tcrb5CC7)IWep/0	involves: 129S/SvEv * C57BL/6 * DBA/2
cx2	Itk^tm1Ljb/Itk^tm1Ljb Rag1^tm1Mom/Rag1^tm1Mom Tg(Tcra5CC7,Tcrb5CC7)IWep/?	involves: 129 * C57BL/10
cx3	Itk^tm1Ljb/Itk^tm1Ljb Tg(Tcra5CC7,Tcrb5CC7)IWep/?	involves: 129 * C57BL/10
cx4	Il2^tm1Hor/Il2^tm1Hor Rag2^tm1Fwa/Rag2^tm1Fwa Tg(Tcra5CC7,Tcrb5CC7)IWep/0	involves: 129P2/OlaHsd * C57BL/10
cx5	Rag2^tm1Fwa/Rag2^tm1Fwa Tg(Tcra5CC7,Tcrb5CC7)IWep/? Themis^5AT161/Themis^5AT161	involves: 129S/SvEv * C57BL/6
tg6	Tg(Tcra5CC7,Tcrb5CC7)IWep/0	involves: C57BL/6

Phenotypes:

Affected Systems	cn1	cx2	cx3	cx4	cx5	tg6
show or hide all annotated terms
hematopoietic system	√	√	√	√	√	√
abnormal T cell differentiation	√
abnormal CD4-positive T cell differentiation		√
arrested T cell differentiation					√
abnormal T cell number				√
increased double-positive T cell number					√
increased T-helper 17 cell number				√
decreased CD4-positive, alpha-beta T cell number			√
abnormal T cell activation						√
immune system	√	√	√	√	√	√
abnormal T cell differentiation	√
abnormal CD4-positive T cell differentiation		√
increased double-positive T cell number					√
arrested T cell differentiation					√
abnormal T cell number				√
increased T-helper 17 cell number				√
decreased CD4-positive, alpha-beta T cell number			√
abnormal T cell activation						√
decreased interferon-gamma secretion		√
decreased interleukin-10 secretion		√
decreased interleukin-4 secretion		√
decreased interleukin-5 secretion		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available

References

• Original: J:124386 Seder RA, et al., The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med. 1992 Oct 1;176(4):1091-8
• All: 74 reference(s)