Lrfn2^{Tg(CD2-Myb/en)5Kmw}
Transgenic Allele Detail

Summary

• Symbol: Lrfn2^{Tg(CD2-Myb/en)5Kmw}
• Name: leucine rich repeat and fibronectin type III domain containing 2; transgene insertion 5, Kathleen Mary Weston
• MGI ID: MGI:3761369
• Synonyms: MEnT5, MEnTCD2.5
• Gene: Lrfn2 Location: Chr17:49239407-49404616 bp, + strand Genetic Position: Chr17, 24.66 cM, cytoband C
• Alliance: Lrfn2^{Tg(CD2-Myb/en)5Kmw} page

Transgene origin

• Strain of Origin: (CBA x C57BL/10)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Lrfn2^{Tg(CD2-Myb/en)5Kmw} expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myb (MGI:97249)	Transgene codes for a fusion protein of mouse Myb and amino acids 2-298 of Drosophila engrailed.

• Mutation details: A transgene containing the human CD2 promoter driving the expression of an in-frame fusion of mouse Myb and amino acids 2-298 of Drosophila engrailed was randomly inserted in reverse orientation within the first intron. The insertion leads to an increase in expression of a normal transcript. Insertion was confirmed by Sourthern blot analysis. (J:125805, J:126456)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrfn2 Mutation: 46 strains or lines available

References

• Original: J:126456 Badiani P, et al., Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev. 1994 Apr 1;8(7):770-82
• All: 2 reference(s)