Tg(CD207-cre)1Dhka
Transgene Detail

Summary

• Symbol: Tg(CD207-cre)1Dhka
• Name: transgene insertion 1, Daniel H Kaplan
• MGI ID: MGI:3761645
• Synonyms: huLangerinCre^tg+, Langerin-Cre, Tg(CD207-cre)1Mjsk
• Transgene: Tg(CD207-cre)1Dhka Location: unknown
• Alliance: Tg(CD207-cre)1Dhka page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(CD207-cre)1Dhka expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  CD207 (50489)

  Cd207

  (MGI:2180021)

• Mutation details: A cre recombinase gene optimized for mammalian codon usage was inserted right after the ATG of exon 1 in a human BAC, which was then injected into oocytes. Insertion of the cre gene was confirmed by PCR on genomic DNA. Cre expression is restricted to all epidermis MHC-II+CD11c+ Langerhans cells but not other CD207 expressing cells. (J:126147)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CD207 (human) Summary of all recombinase alleles driven by CD207. Alliance human CD207 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:126147 Kaplan DH, et al., Autocrine/paracrine TGF{beta}1 is required for the development of epidermal Langerhans cells. J Exp Med. 2007 Oct 29;204(11):2545-52
• All: 24 reference(s)