Ntsr1^tm2Dgen
Targeted Allele Detail

Summary

• Symbol: Ntsr1^tm2Dgen
• Name: neurotensin receptor 1; targeted mutation 1, Deltagen
• MGI ID: MGI:3761722
• Synonyms: NTR1^-
• Gene: Ntsr1 Location: Chr2:180141769-180186772 bp, + strand Genetic Position: Chr2, 103.04 cM, cytoband H1-H4
• Alliance: Ntsr1^tm2Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126020
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A null allele was create by deleting 457 nucleotides including the initiator methionine at nucleotide position 8 and inserting of a neo cassette. RT-PCR and immunohistochemistry were used to confirm the absence of a transcript. (J:126020)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntsr1 Mutation: 31 strains or lines available

References

• Original: J:126020 Pettibone DJ, et al., The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin. J Pharmacol Exp Ther. 2002 Jan;300(1):305-13
• All: 2 reference(s)