Runx3^tm1Itan
Targeted Allele Detail

Summary

• Symbol: Runx3^tm1Itan
• Name: runt related transcription factor 3; targeted mutation 1, Ichior Taniuchi
• MGI ID: MGI:3761811
• Synonyms: Runx3^f, Runx3^flox
• Gene: Runx3 Location: Chr4:134847963-134905301 bp, + strand Genetic Position: Chr4, 67.19 cM
• Alliance: Runx3^tm1Itan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125953
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin selection cassette was placed in an adjacent intron of a coding exon and was subsequently removed, leaving behind a single loxP site. A second loxP site was introduced in a downstream intron to "flox" the coding exon. (J:125953)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Runx3 Mutation: 27 strains or lines available

References

• Original: J:125953 Naoe Y, et al., Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med. 2007 Aug 6;204(8):1749-55
• All: 39 reference(s)