Cbfb^tm1Itan
Targeted Allele Detail

Summary

• Symbol: Cbfb^tm1Itan
• Name: core binding factor beta; targeted mutation 1, Ichiro Taniuchi
• MGI ID: MGI:3761812
• Synonyms: Cbfbeta^f, Cbfbeta^flox
• Gene: Cbfb Location: Chr8:105897306-105944621 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cbfb^tm1Itan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125953
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was placed adjacent to exon 5 and a loxP site was placed in the other flanking intron. The neomycin resistance cassette was subsequently removed by transient expression of Cre recombinase, leaving exon 5 flanked by loxP sites (J:125953)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cbfb Mutation: 36 strains or lines available

References

• Original: J:125953 Naoe Y, et al., Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med. 2007 Aug 6;204(8):1749-55
• All: 44 reference(s)