Tg(Nefh-cre)22Jcol
Transgene Detail

Summary

• Symbol: Tg(Nefh-cre)22Jcol
• Name: transgene insertion 22, John Collinge
• MGI ID: MGI:3761830
• Synonyms: Cre 22, NFH-Cre
• Transgene: Tg(Nefh-cre)22Jcol Location: unknown
• Alliance: Tg(Nefh-cre)22Jcol page

Transgene origin

• Strain of Origin: mixed

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Nefh-cre)22Jcol expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Nefh

• Mutation details: A nuclear localization containing cre open reading frame was inserted into exon 1. The transgene was inserted into Prnp^tm1Cwe oocytes. Insertion was confirmed by Southern blot analysis and cre expression is localized to the brain. (J:74652)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nefh (species not specified) Summary of all recombinase alleles driven by Nefh. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

4 of 5 lines expressed cre (7, 22, 27, and 29) in the brain. Founder 22 was used as the representative line. Eggs of mixed background involve: 129/Sv * C57BL * FVB/N.

References

• Original: J:74652 Mallucci GR, et al., Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration. EMBO J. 2002 Feb 1;21(3):202-10
• All: 7 reference(s)