Tg(KLK3-cre)D4Trp
Transgene Detail

Summary

• Symbol: Tg(KLK3-cre)D4Trp
• Name: transgene insertion D4, Jan Trapman
• MGI ID: MGI:3761848
• Synonyms: PSA-cre, PSA-creD4
• Transgene: Tg(KLK3-cre)D4Trp Location: unknown
• Alliance: Tg(KLK3-cre)D4Trp page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(KLK3-cre)D4Trp expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KLK3 (354)

  Klk1	(MGI:102850)
  Klk1b1	(MGI:892019)
  Klk1b3	(MGI:97322)
  Klk1b4	(MGI:97320)
  Klk1b5	(MGI:892020)
  Klk1b8	(MGI:892018)
  Klk1b9	(MGI:95293)
  Klk1b11	(MGI:892023)
  Klk1b16	(MGI:891982)
  Klk1b21	(MGI:892022)
  Klk1b22	(MGI:95291)
  Klk1b24	(MGI:892021)
  Klk1b26	(MGI:891981)
  Klk1b27	(MGI:891980)

• Mutation details: The construct uses the human prostate-specific antigen promoter (referred to as PSA; proper designation KLK3) to drive transcription of the cre recombinase cDNA. The transgene was injected into fertilized FVB oocytes. Prostate-specific expression was verified by crossing to Tg(ACTB-cat,-lacZ)34Pva transgenic mice. Founder line D4 showed high, prostate-specific cre activity. (J:99524)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KLK3 (human) Summary of all recombinase alleles driven by KLK3. Alliance human KLK3 gene page

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(KLK3-cre)D4Trp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99524 Ma X, et al., Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res. 2005 Jul 1;65(13):5730-9
• All: 7 reference(s)