Del(11Hoxb3-Hoxb4)1Karl
Targeted Allele Detail

Summary

• Symbol: Del(11Hoxb3-Hoxb4)1Karl
• Name: deletion, Chr 11, Stefan Karlsson 1
• MGI ID: MGI:3762002
• Synonyms: Del1Karl, Hoxb3/b4^-
• Gene: Del(11Hoxb3-Hoxb4)1Karl Location: Chr11:96209093-96238756 bp Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83563
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(11Hoxb3-Hoxb4)1Karl involves 5 genes/genome features (Mir10a, Hoxb4, Hoxb3 ...) View all
• Mutation details: Floxed neo cassettes were inserted upstream of Hoxb4 and downstream of Hoxb3. Cre mediated recombination using a transiently expressed cre plasmid was used to create a deletion region that encompasses both genes. The absence of either transcript was confirmed by RT-PCR using RNA extracted from bone marrow cells. (J:83563)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(11Hoxb3-Hoxb4)1Karl Mutation: 1 strain or line available

References

• Original: J:83563 Bjornsson JM, et al., Reduced proliferative capacity of hematopoietic stem cells deficient in hoxb3 and hoxb4. Mol Cell Biol. 2003 Jun;23(11):3872-83
• All: 2 reference(s)