Tg(KRT14-Il1f6)1Hblu
Transgene Detail

Summary

• Symbol: Tg(KRT14-Il1f6)1Hblu
• Name: transgene insertion 1, Hal Blumberg
• MGI ID: MGI:3762035
• Transgene: Tg(KRT14-Il1f6)1Hblu Location: unknown
• Alliance: Tg(KRT14-Il1f6)1Hblu page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Il1f6)1Hblu expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il36a (MGI:1859324)

• Mutation details: The promoter of human KRT14 drives the expression of mouse Il1f5 in basal keratinocytes. At least 70-fold higher mRNA expression compared to in wild-type was detected in mice expressing this transgene. (J:126327)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

9 founders were used to create 4 lines with at least 70-fold higher mRNA expression.

References

• Original: J:126327 Blumberg H, et al., Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J Exp Med. 2007 Oct 29;204(11):2603-14
• All: 2 reference(s)