Cops8^tm1Nwe
Targeted Allele Detail

Summary

• Symbol: Cops8^tm1Nwe
• Name: COP9 signalosome subunit 8; targeted mutation 1, Ning Wei
• MGI ID: MGI:3762119
• Synonyms: Csn8^flox
• Gene: Cops8 Location: Chr1:90531147-90541063 bp, + strand Genetic Position: Chr1, 45.53 cM
• Alliance: Cops8^tm1Nwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126339
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette with a 3' loxP site was inserted between exon 3 and 4, and an additional loxP site was inserted between exons 6 and 7. Flp-mediate recombination to remove the neo cassette was accomplished using Tg(ACTFLPe)9205Dym. Insertion was confirmed by Southern blot analysis and PCR genotyping. (J:126339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cops8 Mutation: 21 strains or lines available

References

• Original: J:126339 Menon S, et al., COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nat Immunol. 2007 Nov;8(11):1236-45
• All: 8 reference(s)