Cops8^tm1.1Nwe
Targeted Allele Detail

Summary

• Symbol: Cops8^tm1.1Nwe
• Name: COP9 signalosome subunit 8; targeted mutation 1.1, Ning Wei
• MGI ID: MGI:3762120
• Synonyms: Csn8^-
• Gene: Cops8 Location: Chr1:90531147-90541063 bp, + strand Genetic Position: Chr1, 45.53 cM
• Alliance: Cops8^tm1.1Nwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126339
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 4 through 6 were deleted by cre-mediated recombination following a cross to Tg(ACTB-cre)2Mrt mice. The absence of protein product in the whole embryo at E7.5 was confirmed by immunohistochemistry. (J:126339)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cops8 Mutation: 21 strains or lines available

References

• Original: J:126339 Menon S, et al., COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nat Immunol. 2007 Nov;8(11):1236-45
• All: 2 reference(s)