Madd^tm1Ytk
Targeted Allele Detail

Summary

• Symbol: Madd^tm1Ytk
• Name: MAP-kinase activating death domain; targeted mutation 1, Yoshimi Takai
• MGI ID: MGI:3762127
• Synonyms: Rab3 GEP^-
• Gene: Madd Location: Chr2:90967705-91013404 bp, - strand Genetic Position: Chr2, 50.46 cM
• Alliance: Madd^tm1Ytk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126869
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' half of exon 1 through the 5' half of exon 2 was replaced with a neo cassette. The lack of protein expression was confirmed by western blot analysis on protein extracted from the brain. (J:126869)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Madd Mutation: 89 strains or lines available

References

• Original: J:126869 Tanaka M, et al., Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell. 2001 May;12(5):1421-30
• All: 2 reference(s)