Scp2^tm1Fsch
Targeted Allele Detail

Summary

• Symbol: Scp2^tm1Fsch
• Name: sterol carrier protein 2, liver; targeted mutation 1, Friedhelm Schroeder
• MGI ID: MGI:3762148
• Synonyms: SCP-2/SCP-x^-
• Gene: Scp2 Location: Chr4:107901027-108002168 bp, - strand Genetic Position: Chr4, 50.2 cM
• Alliance: Scp2^tm1Fsch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126573
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 16 was replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on proteins extracted from the liver and exposed to an antibody that recognizes SCP-2 and SCP-X. (J:126573)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Scp2 Mutation: 59 strains or lines available

References

• Original: J:126573 Atshaves BP, et al., SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes. J Lipid Res. 2007 Oct;48(10):2193-211
• All: 14 reference(s)