Brca1^tm1.1Brn
Targeted Allele Detail

Summary

• Symbol: Brca1^tm1.1Brn
• Name: breast cancer 1, early onset; targeted mutation 1.1, Anton Berns
• MGI ID: MGI:3762184
• Synonyms: Brca1^delta
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm1.1Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126551
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 5 through 13 were removed by cre-mediated expression following expression of a transient cre vector. Southern blot analysis on genomic DNA confirmed the genomic modification. (J:126551)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:126551 Liu X, et al., Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6
• All: 4 reference(s)