Del(2Hoxd4-Hoxd13)30Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd4-Hoxd13)30Ddu
• Name: deletion, Chr 2, Denis Duboule 30
• MGI ID: MGI:3762256
• Synonyms: Del30Ddu, del(4-13), HoxD^d11lacZDel7, HoxD^Del7
• Gene: Del(2Hoxd4-Hoxd13)30Ddu Location: Chr2:74498654-74559504 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92363
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd4-Hoxd13)30Ddu involves 11 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
• Mutation details: This allele involved the use of an embryonic stem cell line carrying an ectopic Hoxd11/lacZ transgene located between the resident Hoxd13 and Evx2 genes and flanked at the 3' end by a unique loxP site. A loxPneoloxP cassette was recombined on the same chromosome, downstream of resident Hoxd4. After treatment with Cre recombinase, the resultant deletion removed Hoxd4, Hoxd8, and Hoxd9, Hoxd10, Hoxd11, Hoxd12, and Hoxd13, but brought the ectopic Hoxd11/lacZ transgene back to the original Hoxd4 locus. Mice homozygous for this deficiency lacked Hoxd4-Hoxd13 loci. (J:92363)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd4-Hoxd13)30Ddu Mutation: 0 strains or lines available

References

• Original: J:92363 Zakany J, et al., Hox genes and the making of sphincters. Nature. 1999 Oct 21;401(6755):761-2
• All: 7 reference(s)