Cacnb2^tm1.1Mfre
Targeted Allele Detail

Summary

• Symbol: Cacnb2^tm1.1Mfre
• Name: calcium channel, voltage-dependent, beta 2 subunit; targeted mutation 1.1, Marc Freichel
• MGI ID: MGI:3762348
• Synonyms: Cavbeta2^-
• Gene: Cacnb2 Location: Chr2:14607899-14992719 bp, + strand Genetic Position: Chr2, 10.7 cM
• Alliance: Cacnb2^tm1.1Mfre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126506
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 16 was removed by cre-mediated recombination. This exon encodes part of the SH3 domain and the guanylate kinase domain. The absence of protein expression was confirmed by western blot analysis on E10.5 hearts. (J:126506)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacnb2 Mutation: 50 strains or lines available

References

• Original: J:126506 Weissgerber P, et al., Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res. 2006 Sep 29;99(7):749-57
• All: 3 reference(s)