Rspo2^tm1Nuv
Targeted Allele Detail

Summary

• Symbol: Rspo2^tm1Nuv
• Name: R-spondin 2; targeted mutation 1, Walter D Funk
• MGI ID: MGI:3762378
• Synonyms: Rspo2-LacZ
• Gene: Rspo2 Location: Chr15:42884190-43034222 bp, - strand Genetic Position: Chr15, 16.73 cM
• Alliance: Rspo2^tm1Nuv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126341
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 308 bp section spanning exon 3 (containing the first half of the cysteine-rich domain) is replaced with an IRES-lacZ-PGKneo cassette. RNA expression analysis fails to detect any transcript in the brains of P1 homozygous mice. LacZ expression recapitulates endogenous gene expression in embryos. (J:126341)

Expression

In Mice Carrying this Mutation:	95 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rspo2 Mutation: 20 strains or lines available

References

• Original: J:126341 Nam JS, et al., Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol. 2007 Nov 1;311(1):124-35
• All: 6 reference(s)