Lime1^tm1.1Mal
Targeted Allele Detail

Summary

• Symbol: Lime1^tm1.1Mal
• Name: Lck interacting transmembrane adaptor 1; targeted mutation 1.1, Bernard Malissen
• MGI ID: MGI:3762394
• Synonyms: Lime^-, Lime1^tm1Mal
• Gene: Lime1 Location: Chr2:181023028-181025421 bp, + strand Genetic Position: Chr2, 103.63 cM, cytoband H4
• Alliance: Lime1^tm1.1Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126321
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-5, which contain the entire coding region of the gene, were replaced with a loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site. After Cre-mediated self-excision in the male germline, a single loxP site remained in place of the gene. (J:126321)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lime1 Mutation: 6 strains or lines available

References

• Original: J:126321 Gregoire C, et al., Deletion of the LIME adaptor protein minimally affects T and B cell development and function. Eur J Immunol. 2007 Nov;37(11):3259-69
• All: 2 reference(s)