Dusp1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Dusp1^tm1Lex
• Name: dual specificity phosphatase 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3762529
• Synonyms: MPK-1
• Gene: Dusp1 Location: Chr17:26724565-26727446 bp, - strand Genetic Position: Chr17, 13.28 cM, cytoband A2-C
• Alliance: Dusp1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126383
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 2812 bp containing the coding exons 1-4 of the gene were replaced with a LacZ/Neo selection cassette. Homologous recombination was confirmed by Southern blotting and by quantitative PCR analysis for the neomycin expression. (J:126383)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dusp1 Mutation: 25 strains or lines available

References

• Original: J:126383 Salojin KV, et al., Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol. 2006 Feb 1;176(3):1899-907
• All: 5 reference(s)