Trp53^tm4Xu
Targeted Allele Detail

Summary

• Symbol: Trp53^tm4Xu
• Name: transformation related protein 53; targeted mutation 4, Yang Xu
• MGI ID: MGI:3762530
• Synonyms: p53^R248W
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm4Xu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126497
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette and a human gene fragment containing an amino acid substitution of tryptophan for arginine at position 248 (p.R248W) replaced intron 4 through 10. The neo cassette was removed by Cre-mediated recombination. The presence of the mutations was confirmed by Southern blot and sequence analysis. (J:126497)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm4Xu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:126497 Song H, et al., p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol. 2007 May;9(5):573-80
• All: 6 reference(s)