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Trp53tm5Xu
Targeted Allele Detail
Summary
Symbol: Trp53tm5Xu
Name: transformation related protein 53; targeted mutation 5, Yang Xu
MGI ID: MGI:3762531
Synonyms: p53R273H
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm5Xu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126497
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site flanked neomycin resistance gene cassette and a human gene fragment containing an amino acid substitution of histidine with arginine at position 273 (p.R273H) replaced intron 4 through 10. The neo cassette was removed by cre-mediated recombination. The presence of the mutations was confirmed by Southern blot and sequence analysis. (J:126497)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  239 strains or lines available
References
Original:  J:126497 Song H, et al., p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol. 2007 May;9(5):573-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory