Trp53tm5Xu
Targeted Allele Detail
|
|
| Symbol: |
Trp53tm5Xu |
| Name: |
transformation related protein 53; targeted mutation 5, Yang Xu |
| MGI ID: |
MGI:3762531 |
| Synonyms: |
p53R273H |
| Gene: |
Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
|
| Alliance: |
Trp53tm5Xu page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:126497
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
Not Specified
|
|
| Allele Type: |
|
Targeted (Humanized sequence) |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Mutation details: A loxP site flanked neomycin resistance gene cassette and a human gene fragment containing an amino acid substitution of histidine with arginine at position 273 (p.R273H) replaced intron 4 through 10. The neo cassette was removed by cre-mediated recombination. The presence of the mutations was confirmed by Southern blot and sequence analysis.
(J:126497)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Trp53 Mutation: |
240 strains or lines available
|
|
| Original: |
J:126497 Song H, et al., p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol. 2007 May;9(5):573-80 |
| All: |
1 reference(s) |
|
Analysis Tools
