Grn^tm1Mni
Targeted Allele Detail

Summary

• Symbol: Grn^tm1Mni
• Name: granulin; targeted mutation 1, Masugi Nishihara
• MGI ID: MGI:3762618
• Synonyms: pgrn^-
• Gene: Grn Location: Chr11:102321333-102327635 bp, + strand Genetic Position: Chr11, 66.29 cM
• Alliance: Grn^tm1Mni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126370
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.7 kb fragment encoding exons 2 - 13 was replaced with a PGK-neo-bpA cassette. RT-PCR analysis confirmed the absence of transcript in the brain, epididymis, testis, lung and liver. (J:126370)

Expression

In Mice Carrying this Mutation:

4 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grn Mutation: 48 strains or lines available

References

• Original: J:126370 Kayasuga Y, et al., Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. Behav Brain Res. 2007 Dec 28;185(2):110-8
• All: 41 reference(s)