Git1^{Gt(FHCRC-GT-S10-12C1)Sor}
Gene trapped Allele Detail

Summary

• Symbol: Git1^{Gt(FHCRC-GT-S10-12C1)Sor}
• Name: GIT ArfGAP 1; gene trap FHCRC-GT-S10-12C1, Philippe Soriano
• MGI ID: MGI:3762634
• Synonyms: GIT1^-
• Gene: Git1 Location: Chr11:77384388-77398612 bp, + strand Genetic Position: Chr11, 46.61 cM
• Alliance: Git1^{Gt(FHCRC-GT-S10-12C1)Sor} page

Mutation origin

• Mutant Cell Line: S10-12C1
• Germline Transmission: Earliest citation of germline transmission: J:126878
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: ROSAFARY
• Mutation details: The gene trap vector containing a beta-geo cassette and a PGK-hygro cassette was inserted into intron 1. Insertion was confirmed by genomic PCR and expression of the lacZ cassette was confirmed by beta-galactosidase staining. (J:126878)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  FHCRC-GT-S10-12C1	CL256252 ; (MGI Seq Detail)	3' RACE	Chr11:77389790-77391939 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  17 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Git1 Mutation: 42 strains or lines available

References

• Original: J:126878 Schmalzigaug R, et al., Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. J Histochem Cytochem. 2007 Oct;55(10):1039-48
• All: 5 reference(s)