Lgr4^tm1.2Knis
Targeted Allele Detail

Summary

• Symbol: Lgr4^tm1.2Knis
• Name: leucine-rich repeat-containing G protein-coupled receptor 4; targeted mutation 1.2, Katsuhiko Nishimori
• MGI ID: MGI:3762641
• Gene: Lgr4 Location: Chr2:109747992-109844602 bp, + strand Genetic Position: Chr2, 56.65 cM
• Alliance: Lgr4^tm1.2Knis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127019
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination removed an Frt-flanked neo cassette and the part of exon 18 which codes for the transmembrane and signal-transducing domains. Immunostaining confirms the absence of expression in the protruding tips of the eyelids and in epithelial cells of the cornea. (J:126813, J:127019)

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgr4 Mutation: 94 strains or lines available

References

• Original: J:127019 Kato S, et al., Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice. Nephron Exp Nephrol. 2006;104(2):e63-75
• All: 8 reference(s)