Lcmt1^{Gt(A050A04)Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Lcmt1^{Gt(A050A04)Wrst}
• Name: leucine carboxyl methyltransferase 1; gene trap A050A04, Wolfgang Wurst
• MGI ID: MGI:3762662
• Synonyms: LCMT 1^-, LCMT-1^-
• Gene: Lcmt1 Location: Chr7:122977026-123029581 bp, + strand Genetic Position: Chr7, 67.42 cM
• Alliance: Lcmt1^{Gt(A050A04)Wrst} page

Mutation origin

• Mutant Cell Line: A050A04
• Germline Transmission: Earliest citation of germline transmission: J:126819
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pT1betageo
• Mutation details: A gene trap vector, pT1betageo, was inserted into the first intron of the gene. Protein was reduced about 2-fold in the heterozygous ES cells by immunoblot. Homozygosity is embryonic lethal. (J:126819)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  A050A04	CL213365 ; (MGI Seq Detail)	5' RACE	Chr7:122977264-122977477 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  13 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcmt1 Mutation: 36 strains or lines available

References

• Original: J:126819 Lee JA, et al., Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells. J Biol Chem. 2007 Oct 19;282(42):30974-84
• All: 4 reference(s)