Emx1^{tm1.1(cre)Ito}
Targeted Allele Detail

Summary

• Symbol: Emx1^{tm1.1(cre)Ito}
• Name: empty spiracles homeobox 1; targeted mutation 1.1, Shigeyoshi Itohara
• MGI ID: MGI:3762664
• Synonyms: Emx1-Cre KI deltaneo, Emx1^tm2(cre)Ito
• Gene: Emx1 Location: Chr6:85164913-85181445 bp, + strand Genetic Position: Chr6, 37.21 cM
• Alliance: Emx1^{tm1.1(cre)Ito} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88421
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Emx1^{tm1.1(cre)Ito} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Emx1 (MGI:95387)

• Mutation details: A cDNA encoding Cre recombinase with an N-terminal nuclear localization signal (nls) resides immediately 5' of the translation initiation site of the endogenous gene. This allele was derived from Emx1^tm1(cre)Ito by FLP recombinase excision of a FRT-flanked pgk-neo cassette that lay immediately downstream of the nls-cre gene. The Emx1 promoter drives Cre recombinase expression in the embryonic through adult dorsal telencephelon; deletion of the selection cassette reportedly prevents ectopic expression in other brain regions. (J:64064, J:104881)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Emx1 (mouse) Summary of all recombinase alleles driven by Emx1. Alliance mouse Emx1 gene page

Expression

In Mice Carrying this Mutation:

51 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Emx1 Mutation: 34 strains or lines available

References

• Original: J:88421 Iwasato T, et al., Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis. 2004 Mar;38(3):130-8
• All: 52 reference(s)