Shank1^tm1Shng
Targeted Allele Detail

Summary

• Symbol: Shank1^tm1Shng
• Name: SH3 and multiple ankyrin repeat domains 1; targeted mutation 1, Morgan Sheng
• MGI ID: MGI:3762757
• Gene: Shank1 Location: Chr7:43959677-44009996 bp, + strand Genetic Position: Chr7, 28.83 cM
• Alliance: Shank1^tm1Shng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132277
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 14 and 15, encoding almost the entire PDZ domain, with a PGK-neomycin drug resistance cassette. The absence of protein product was confirmed by western blot analysis on forebrain membrane extracts. (J:132277)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Shank1 Mutation: 98 strains or lines available

References

• Original: J:132277 Hung AY, et al., Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. J Neurosci. 2008 Feb 13;28(7):1697-708
• All: 12 reference(s)