Pdcd1^tm1Llc
Targeted Allele Detail

Summary

• Symbol: Pdcd1^tm1Llc
• Name: programmed cell death 1; targeted mutation 1, Laura L Carter
• MGI ID: MGI:3762771
• Synonyms: PD-1^-
• Gene: Pdcd1 Location: Chr1:93966027-93980278 bp, - strand Genetic Position: Chr1, 47.47 cM
• Alliance: Pdcd1^tm1Llc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126829
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted
• Mutation: Disruption caused by insertion of vector
• Mutation details: The cDNA for human PDCD1, encompassing sequence from kozak through translational stop and the last 2 exons of a mouse metallothionein gene including the terminal intron followed by a neo mini-gene flanked by loxP sites replaced the coding portion of murine exon 1 in order to maintain correct splicing of the fusion transcript. Flow cytometric protein expression analysis confirmed absence of targeted protein expression. (J:126829)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1 Mutation: 97 strains or lines available

References

• Original: J:126829 Carter LL, et al., PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2007 Jan;182(1-2):124-34
• All: 1 reference(s)