Pdcd1lg2tm1.1Lex
Targeted Allele Detail
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Symbol: |
Pdcd1lg2tm1.1Lex |
Name: |
programmed cell death 1 ligand 2; targeted mutation 1.1, Lexicon Genetics |
MGI ID: |
MGI:3762772 |
Synonyms: |
PD-L2- |
Gene: |
Pdcd1lg2 Location: Chr19:29388319-29448561 bp, + strand Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
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Alliance: |
Pdcd1lg2tm1.1Lex page
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Germline Transmission: |
Earliest citation of germline transmission:
J:126829
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEvBrd
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Project Collection: |
Lexicon
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: By homologous recombination a loxP site was inserted 5' of exon2, followed by a NeoR cassette and a 3' loxP site. The resulting mutant mice, Pdcd1lg2tm1Lex were crossed with protamine-Cre transgenic mice to delete exon 2 containing the translational start site. Flow cytometric protein expression analysis confirmed absence of targeted protein expression.
(J:126829)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pdcd1lg2 Mutation: |
25 strains or lines available
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Original: |
J:126829 Carter LL, et al., PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2007 Jan;182(1-2):124-34 |
All: |
1 reference(s) |
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