Tg(Prnp-PRNP*129V)139Tkit
Transgene Detail

Summary

• Symbol: Tg(Prnp-PRNP*129V)139Tkit
• Name: transgene insertion 139, Tetsuyuki Kitamoto
• MGI ID: MGI:3762801
• Synonyms: Tg-Hu129V, Tg-V#139, TK-Hu129V
• Transgene: Tg(Prnp-PRNP*129V)139Tkit Location: unknown
• Alliance: Tg(Prnp-PRNP*129V)139Tkit page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-PRNP*129V)139Tkit expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRNP (5621)

  Prnp	(MGI:97769)

• Mutation details: The transgene contains the human variant of PRNP with a valine at amino acid position 129 under the control of the mouse promoter. (J:105882)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic mice do not produce PrP^c in follicular dendritic cells.

References

• Original: J:105882 Asano M, et al., vCJD prion acquires altered virulence through trans-species infection. Biochem Biophys Res Commun. 2006 Mar 31;342(1):293-9
• All: 3 reference(s)