Irak4^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Irak4^tm1Aki
• Name: interleukin-1 receptor-associated kinase 4; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3762874
• Synonyms: IRAK-4^-
• Gene: Irak4 Location: Chr15:94441495-94466198 bp, + strand Genetic Position: Chr15, 48.55 cM, cytoband F1
• Alliance: Irak4^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125729
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was constructed so that exon 2 was replaced with a floxed neomycin resistance cassette. Absence of protein was confirmed by western analysis of macrophage extract from homozygotes. (J:125729)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irak4 Mutation: 32 strains or lines available

References

• Original: J:125729 Kawagoe T, et al., Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J Exp Med. 2007 May 14;204(5):1013-24
• All: 1 reference(s)