Cblb^tm1Wlan
Targeted Allele Detail

Summary

• Symbol: Cblb^tm1Wlan
• Name: Casitas B-lineage lymphoma b; targeted mutation 1, Wallace Y Langdon
• MGI ID: MGI:3762926
• Synonyms: Cbl-b BR, Cbl-b(C373A)
• Gene: Cblb Location: Chr16:51851593-52028410 bp, + strand Genetic Position: Chr16, 32.88 cM
• Alliance: Cblb^tm1Wlan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126361
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector introduced a cysteine (TGC) to alanine (GCG) substitution at amino acid position 373 (C373A) encoded within exon 8. A loxP flanked pGKNeo cassette was removed by crossing mice with Cre-transgenic mice, leaving behind a single loxP site. Western analysis of bone marrow derived mast cells from homozygotes indicated protein expression was similar to wild-type protein. (J:126361)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cblb Mutation: 58 strains or lines available

References

• Original: J:126361 Oksvold MP, et al., The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells. Mol Immunol. 2008 Feb;45(4):925-36
• All: 12 reference(s)