Meg3^tm1.1Jvs
Targeted Allele Detail

Summary

• Symbol: Meg3^tm1.1Jvs
• Name: maternally expressed 3; targeted mutation 1.1, Jennifer Schmidt
• MGI ID: MGI:3763115
• Synonyms: Gtl2delta5'
• Gene: Meg3 Location: Chr12:109506879-109538163 bp, + strand Genetic Position: Chr12, 60.25 cM
• Alliance: Meg3^tm1.1Jvs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125994
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: A floxed neo cassette replaced 2.8 kb of upstream sequence between -1.3 kb and -4.1 kb from the initiation site. The neo cassette was removed by cre-mediated recombination following a cross to Tg(EIIa-cre)C5379Lmgd mice. Insertion was confirmed by PCR genotyping on embryonic stem cells. (J:125994)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meg3 Mutation: 4 strains or lines available

References

• Original: J:125994 Steshina EY, et al., Loss of imprinting at the Dlk1-Gtl2 locus caused by insertional mutagenesis in the Gtl2 5' region. BMC Genet. 2006;7:44
• All: 1 reference(s)